hrp0095p1-36 | Diabetes and Insulin | ESPE2022

Human umbilical cord derived mesenchymal stem cells alleviate T1DM model via TGFBI-mediated T cells proliferation

Wu Chushan , Xu Tingting , Li Lu , zheng Rongxiu

Type 1 diabetes mellitus is autoimmune T cells mediated destruction of β-cells. Mesenchymal stem cells (MSCs) are considered a promising treatment for T1DM due to the strong immunosuppressive and regenerative capacity. However, the comprehensive mechanism is still unclear. Our previous study indicated that the transforming growth factor beta-induced gene (TGFBI) is highly expressed in human umbilical cord derived mesenchymal stem cells (hUC-MSCs), which is also implicated...